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Key Documents

P4083

Sigma-Aldrich

Penicillin − Streptomycin − Neomycin Solution Stabilized

liquid, suitable for cell culture, BioReagent

Synonym(s):

Pen-Strep-Neo

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About This Item

UNSPSC Code:
12352207
NACRES:
NA.76

product name

Penicillin − Streptomycin − Neomycin Solution Stabilized, formulated to contain ~5,000 units penicillin, 5 mg streptomycin and 10 mg neomycin/mL, 0.1 μm filtered, BioReagent, suitable for cell culture

Quality Level

300

sterility

0.1 μm filtered

product line

BioReagent

form

liquid

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

cell wall synthesis | interferes
protein synthesis | interferes

shipped in

dry ice

storage temp.

−20°C

Application

Penicillin-Streptomycin-Neomycin Solution Stabilized has been used to immerse alginate scaffold for disinfection. It has also been used as a cell culture media supplement to control bacterial contamination.

Biochem/physiol Actions

Mode of Action: This product acts in three ways. Penicillin inhibits bacterial cell wall synthesis. Streptomycin inhibits prokaryote protein synthesis by preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding. Neomycin inhibits initiation and elongation during protein synthesis.

Components

This product is formulated to contain 5,000 units penicillin, 5 mg streptomycin and 10 mg neomycin/mL and is solubilized.

Other Notes

20ml,100ml
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cartilage regeneration in SCID mice using a highly organized three-dimensional alginate scaffold
Wang CC, et al.
Biomaterials and Medical Tribology, 33(1), 120-127 (2012)
Goro Tanifuji et al.
Scientific reports, 7(1), 11688-11688 (2017-09-17)
Endosymbiotic relationships between eukaryotic and prokaryotic cells are common in nature. Endosymbioses between two eukaryotes are also known; cyanobacterium-derived plastids have spread horizontally when one eukaryote assimilated another. A unique instance of a non-photosynthetic, eukaryotic endosymbiont involves members of the
Rich-club organization in effective connectivity among cortical neurons
Nigam S, et al.
The Journal of Neuroscience, 36(3), 670-684 (2016)
Seweryn Mroczek et al.
Nature communications, 8(1), 619-619 (2017-09-22)
FAM46C is one of the most frequently mutated genes in multiple myeloma. Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression.
Craig Myrum et al.
Frontiers in cellular neuroscience, 11, 294-294 (2017-10-06)
Activity-regulated cytoskeleton-associated protein, Arc, is a major regulator of long-term synaptic plasticity and memory formation. Here we reveal a novel interaction partner of Arc, a resident endoplasmic reticulum transmembrane protein, calnexin. We show an interaction between recombinantly-expressed GST-tagged Arc and
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