M5324

PX 12

≥98% (HPLC), powder

• Synonym(s): 2-[(1-methylpropyl)dithio]-1H-imidazole
• Empirical Formula (Hill Notation): C₇H₁₂N₂S₂
• CAS Number: 141400-58-0
• Molecular Weight: 188.31
• MDL number: MFCD18086851
• UNSPSC Code: 12352200
• PubChem Substance ID: 329818011
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: off-white to tan
• solubility: DMSO: >25 mg/mL
• storage temp.: 2-8°C
• SMILES string: CCC(C)SSc1ncc[nH]1
• InChI: 1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
• InChI key: BPBPYQWMFCTCNG-UHFFFAOYSA-N

Description

Application

PX 12 has been used as a thioredoxin 1 inhibitor prostate cancer cell lines to analyse its effect on cell viability. It has also been used as a hypoxia-inducible factor (HIF)-1α inhibitor to treat H2228 cells.

Biochem/physiol Actions

PX-12 inhibits the thioredoxin redox system and HIF-1a activity. PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable