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I8283

Sigma-Aldrich

ICI 63,197

≥98% (HPLC)

Synonym(s):

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one

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About This Item

Empirical Formula (Hill Notation):
C9H13N5O
CAS Number:
27277-00-5
Molecular Weight:
207.23
EC Number:
248-383-5
MDL number:
MFCD06407961
UNSPSC Code:
41106305
PubChem Substance ID:
24896137
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white

mp

161.8-163 °C

solubility

DMSO: 13 mg/mL

storage temp.

2-8°C

SMILES string

CCCN1C(=O)C(C)=Cn2nc(N)nc12

InChI

1S/C9H13N5O/c1-3-4-13-7(15)6(2)5-14-9(13)11-8(10)12-14/h5H,3-4H2,1-2H3,(H2,10,12)

InChI key

UQDVRVNMIJAGRK-UHFFFAOYSA-N

Biochem/physiol Actions

Phosphodiesterase IV (PDE 4) inhibitor

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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T Hermsdorf et al.
Cellular signalling, 10(9), 629-635 (1998-10-30)
Primary cultures of rat hepatocytes were used to study the combined effects of insulin and dexamethasone on cyclic AMP phosphodiesterase 3 (PDE 3) and glycogen metabolism. PDE activity was measured in extracts obtained by hypotonic shock treatment of the particulate
A Bobik et al.
Journal of cardiovascular pharmacology, 6(5), 795-801 (1984-09-01)
We examined the effects of prolonged exposure of cardiac cells in primary culture to the partial beta-adrenoceptor agonist prenalterol and inhibitors of phosphodiesterase on their subsequent ability to increase intracellular cyclic AMP during a 5-min exposure to 50 microM isoprenaline
C B Archer et al.
The British journal of dermatology, 109(5), 559-564 (1983-11-01)
Peripheral blood lymphocyte cyclic AMP responses to isoprenaline, prostaglandin E2 and histamine were examined in patients with atopic eczema, in the presence and absence of a potent phosphodiesterase inhibitor (PDEI). Basal cyclic AMP levels were not significantly different in atopic
H Wachtel
Psychopharmacology, 77(4), 309-316 (1982-01-01)
The significance of a characteristic symptomatology (hypothermia, hypoactivity, forepaw shaking, grooming, head twitches) as a potential in vivo correlate of enhanced availability of brain adenosine cyclic 3',5'-monophosphate (cAMP) was examined in rats following systemic administration of various doses of dibutyryladenosine
H O Collier et al.
Federation proceedings, 40(5), 1513-1518 (1981-04-01)
A quasi-morphine withdrawal syndrome (QMWS) is a pattern of behavior closely resembling the true withdrawal syndrome in the opiate-dependent animal, which can be elicited acutely by a nonopiate drug in an opiate-naive animal. The main criteria proposed for the QMWS
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