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Key Documents

F5132

Sigma-Aldrich

Factor II from human plasma

lyophilized powder, 5-20 units/mg protein

Synonym(s):

Prothrombin

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About This Item

CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352200

form

lyophilized powder

specific activity

5-20 units/mg protein

UniProt accession no.

foreign activity

factor X <0.01% of base activity
thrombin, none detected

storage temp.

−20°C

Gene Information

human ... F2(2147)

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Biochem/physiol Actions

Plasma phospholipid binding protein; binds to endothelial cells, promotes clotting on the cell surfaces.

Unit Definition

One unit is the amount contained in one mL of normal human plasma.

Reconstitution

When reconstituted with 1 ml of deionized water, solution will contain the indicated activity in 0.5 M NaCl, 0.05 M Tris-HCl, pH 8.0.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Maria M Aleman et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(8), 1829-1836 (2013-06-01)
Individuals with elevated prothrombin, including those with the prothrombin G20210A mutation, have increased risk of venous thrombosis. Although these individuals do not have increased circulating prothrombotic biomarkers, their plasma demonstrates increased tissue factor-dependent thrombin generation in vitro. The objectives of
Yuichiro Yanagida et al.
Surgery, 154(1), 48-57 (2013-05-21)
We tested the hypotheses that an increase in systemic thrombin activity occurs in both disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype and in acute coagulopathy of trauma shock (ACoTS), and that the patients diagnosed as having ACoTS overlap or
Masahiko Tameda et al.
Cancer science, 104(6), 725-731 (2013-03-14)
Serum tumor markers, including α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP), are currently used in the diagnosis of hepatocellular carcinoma (HCC). There is, however, an aberrant increase in serum DCP in patients with obstructive jaundice, vitamin K deficiency or who are
Marc A Bailey et al.
Journal of vascular surgery, 57(6), 1512-1518 (2013-03-16)
Abdominal aortic aneurysm (AAA) is associated with hypercoagulability, evidenced by increased markers of coagulation activation, including thrombin-antithrombin complex (TAT), prothrombin fragments 1 and 2 (F1+2), and D-dimer. Our aim was to compare the effect of endovascular aneurysm repair (EVAR) and
Atsushi Nanashima et al.
Anticancer research, 33(6), 2689-2697 (2013-06-12)
Although the protein-induced vitamin K absence or antagonist-II (PIVKA-II) is used as a prognostic marker in hepatocellular carcinoma (HCC), a newly-improved assay, NX-PVKA (PIVKA-II measured using P-11 and P-16 antibodies) and NX-PVKA-R (ratio of PIVKA-II and NX-PVKA), are more accurate

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