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Key Documents

COO/COA

EHU111901

MISSION^® esiRNA

Name: MISSION<SUP>®</SUP> esiRNA
Brand: SIGMA

targeting human NLRX1

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About This Item

UNSPSC Code:

41105324

NACRES:

NA.51

description

product line

MISSION^®

form

lyophilized powder

esiRNA cDNA target sequence

GGCGGTGTCAGAATACTGGTCAGTGATCCTCAGTGAAGTCCAGCGGAACCTCAATAGCTGGGATCGGGCCCGGGTTCAGCGACACCTTGAGCTCCTACTGCGGGATCTGGAAGATAGCCGGGGTGCCACCCTTAATCCTTGGCGCAAGGCCCAGCTGCTGCGAGTGGAGGGCGAGGTCAGGGCCCTCCTGGAGCAGCTGGGAAGCTCTGGAAGCTGAGACACTGGCGGCAGGCACCTAGCTATGTGACCACTGGCCCTAAACCTTTTCCCTCTGTGGCCTCCTGGCTTGCACTGCTCCCTCTAGAAAGATTCCTTCAGGTCTGGAGGCAGAGGAATGGGCATAGCTGAGCCAGTTGCCCTCCTAGGGCATGTTTGACCAGGACTGAGTCTGGAATCTCCAAGTTAAAGATGGTGAATCAATGCTTCGGGCTTGGAGATGGAACATGCCT

Ensembl | human accession no.

ENSG00000160703

NCBI accession no.

NM_024618

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... NLRX1(79671) , NLRX1(79671)

Related Categories

MISSION® esiRNA

General description

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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NLRX1 alleviates lipopolysaccharide-induced apoptosis and inflammation in chondrocytes by suppressing the activation of NF-κB signaling.

Ding Ma et al.

International immunopharmacology, 71, 7-13 (2019-03-13)

Osteoarthritis (OA) is a chronic debilitating disease characterized by joint degeneration. Excessive chondrocyte apoptosis and inflammation contributes to articular cartilage destruction in OA pathology. Nucleotide-binding oligomerization domain (NOD)-like receptor X1 (NLRX1) has emerged as a critical regulator of inflammation that

NLRX1 accelerates cisplatin-induced ototoxity in HEI-OC1 cells via promoting generation of ROS and activation of JNK signaling pathway.

Haiyan Yin et al.

Scientific reports, 7, 44311-44311 (2017-03-14)

Nucleotide-binding domain and leucine-rich-repeat-containing family member X1 (NLRX1), located in mitochondria, can recognize cytoplasmic pattern recognition receptors and is tightly related to reactive oxygen species (ROS) production, mitochondrial function, apoptosis and inflammation. The present study was designed to explore whether

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