E3539

Proteinase 3 from human leukocytes

≥95% (PAGE)

• Synonym(s): AGP7, Myeloblastin, P29B, PR-3, PR3 Ag
• Enzyme Commission number: 3.4.21.76 (BRENDA, IUBMB)
• MDL number: MFCD03458212
• UNSPSC Code: 12352204
• NACRES: NA.54

Properties

• Assay: ≥95% (PAGE)
• form: buffered aqueous solution
• UniProt accession no.: P24158
• storage temp.: −20°C
• Gene Information: human ... PRTN3(5657)

Description

General description

Proteinase 3 is found in high concentration in the primary granules of myeloid leukemia blasts.⁴

Application

Proteinase 3 has been shown to be important in the pathogenesis of human emphysema.¹ It has also been used in a study to investigate the liberation of the antibacterial and cytotoxic peptide LL-37 by cleavage of human cathelicidin hCAP-183.²

Biochem/physiol Actions

Proteinase 3 (PR-3) is a serine protease expressed in the granules of neutrophils and monocytes. Also known as myeloblastin and p29b, it degrades elastin and is associated with myeloid leukemia and Wegener′s granulomatosis.³

Used for the detection of anti-PR3 auto-antibodies in immunoassays.

Physical form

Solution in 50 mM sodium acetate (pH 5) with 600 mM sodium chloride

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable