E006
β-Carboline-3-carboxylic acid N-methylamide
Synonym(s):
β-CCA methylamide, FG-7142, N-Methyl-β-carboline-3-carboxamide
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All Photos(3)
About This Item
Empirical Formula (Hill Notation):
C13H11N3O
CAS Number:
Molecular Weight:
225.25
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
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form
solid
Quality Level
color
light tan
solubility
DMSO: >10 mg/mL
H2O: insoluble
SMILES string
CNC(=O)c1cc2c(cn1)[nH]c3ccccc23
InChI
1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17)
InChI key
QMCOPDWHWYSJSA-UHFFFAOYSA-N
Gene Information
human ... BZRAP1(9256)
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Biochem/physiol Actions
Benzodiazepine inverse receptor agonist; potent anxiogenic agent.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Caution
Solutions may be stored for several days at 4 °C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Andrew R Delamater et al.
Journal of experimental psychology. Animal behavior processes, 35(2), 224-237 (2009-04-15)
Previous research has reported a role for the neurotransmitter gamma-aminobutyric acid (GABA) in the extinction and renewal of conditioned fear. Here, the authors examine whether GABA is involved in the acquisition, extinction, renewal, spontaneous recovery, and latent inhibition of appetitive
Kwok Ho C Choy et al.
Psychopharmacology, 221(4), 649-657 (2011-12-24)
Vigilant scanning of the environment is a major risk assessment activity in many species. However, due to difficulties in its manual scoring, scanning has rarely been quantified in laboratory rodent studies. We developed a novel method for automated measurement of
Sarah I Martire et al.
Behavioural brain research, 209(1), 131-136 (2010-02-02)
Three experiments used intake, clusters, and licks per cluster to study the effects of the GABA inverse agonist, FG 7142, on sensory-specific satiety in rats. In Experiment 1, rats were offered one of two palatable solutions and 30min later tested
Joshua B B Garfield et al.
Behavioral neuroscience, 123(1), 75-85 (2009-01-28)
Six experiments studied the role of GABA-sub(A) receptor activation in expression of overexpectation of Pavlovian fear conditioning. After separate pairings of CSA and CSB with shock in Stage I, rats received pairings of the compound AB with shock in Stage
Hongrun Yu et al.
PloS one, 7(8), e42684-e42684 (2012-08-29)
Post-traumatic stress disorder (PTSD) is an anxiety disorder that not only affects mental health, but may also affect bone health. However, there have been no studies to examine the direct relationship between PTSD and bone. We employed electric shocks in
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