B6769

des-Arg⁹-[Leu⁸]-Bradykinin acetate salt

≥97% (HPLC)

• Synonym(s): Arg-Pro-Pro-Gly-Phe-Ser-Pro-Leu
• Empirical Formula (Hill Notation): C₄₁H₆₃N₁₁O₁₀
• CAS Number: 115035-45-5
• Molecular Weight: 870.01
• MDL number: MFCD00133250
• UNSPSC Code: 12352209
• PubChem Substance ID: 329773283
• NACRES: NA.26

Properties

• product name: des-Arg⁹-[Leu⁸]-Bradykinin acetate salt, ≥97% (HPLC)
• Quality Level: 200
• Assay: ≥97% (HPLC)
• form: powder
• color: white
• storage temp.: −20°C
• SMILES string: CC(O)=O.CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCNC(N)=N)C(O)=O
• InChI: 1S/C41H63N11O10.C2H4O2/c1-24(2)20-28(40(61)62)48-36(57)31-14-8-17-50(31)38(59)29(23-53)49-34(55)27(21-25-10-4-3-5-11-25)47-33(54)22-46-35(56)30-13-7-18-51(30)39(60)32-15-9-19-52(32)37(58)26(42)12-6-16-45-41(43)44;1-2(3)4/h3-5,10-11,24,26-32,53H,6-9,12-23,42H2,1-2H3,(H,46,56)(H,47,54)(H,48,57)(H,49,55)(H,61,62)(H4,43,44,45);1H3,(H,3,4)/t26-,27-,28-,29-,30-,31-,32-;/m0./s1
• InChI key: XBFMNOKHQZCARQ-XXZMQFNDSA-N

Description

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Leu

Application

The Bradkykinin amid peptide des-Arg9-[Leu8]-Bradykinin is used as a bradykinin-1 receptor (B1R) antagonist frequently in comparison with the B1 receptor agonist des-Arg9-bradykinin.

Biochem/physiol Actions

Bradykinin receptor antagonist.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves