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B1758

Sigma-Aldrich

Biocytin hydrochloride

≥98% (TLC), suitable for drug transporter assays

Synonym(s):

Nε-Biotinyl-L-lysine

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About This Item

Empirical Formula (Hill Notation):
C16H28N4O4S · xHCl
CAS Number:
98930-70-2
Molecular Weight:
372.48 (free base basis)
MDL number:
MFCD00136057
UNSPSC Code:
12352209
PubChem Substance ID:
24891609
NACRES:
NA.26

product name

Biocytin hydrochloride, ≥98% (TLC)

Quality Level

200

Assay

≥98% (TLC)

form

powder

technique(s)

drug transporter assay: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

Cl.NC(CCCCNC(=O)CCCCC1SCC2NC(=O)NC12)C(O)=O

InChI

1S/C16H28N4O4S.ClH/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14;/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24);1H

InChI key

FMGQMNFQNPUYBS-UHFFFAOYSA-N

Related Categories

Application


  • Biotinylated dextran amine and biocytin hydrochloride are useful tracers for the study of retinal projections in the frog.: This paper highlights the application of biocytin hydrochloride in tracing retinal projections in amphibians. The study demonstrates the efficacy of biocytin hydrochloride in neuroanatomical mapping, facilitating research in visual system development and function (Scalia et al., 1997).


Biochem/physiol Actions

Biocytin is used as a substrate to study the specificity and kinetics of biotinidase(s), to measure biotinidase deficiency and as a model compound to study various uptake mechanisms of cells and tissues.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Barry Wolf et al.
Molecular genetics and metabolism, 86(1-2), 44-50 (2005-09-10)
Biotinidases from various species ranging from fungi and insects to human have specific amino acids, and regions that are evolutionarily conserved. These specific amino acids and regions are further supported by their homology to a variety of amidases and nitrilases
Alessandro R Galloni et al.
eLife, 9 (2020-05-29)
Anatomical similarity across the neocortex has led to the common assumption that the circuitry is modular and performs stereotyped computations. Layer 5 pyramidal neurons (L5PNs) in particular are thought to be central to cortical computation because of their extensive arborisation
Barbara Baur et al.
Brain research, 925(2), 111-121 (2002-01-17)
Uptake of biocytin and biotin was investigated in cultured transformed variants of neuronal (NB2a neuroblastoma) and glial (C6 astrocytoma) CNS cells. NB2a cells took up both compounds but biocytin was transported more efficiently than biotin in the nanomolar concentration range.
Aysun Pabuçcuoğlu et al.
Journal of pediatric gastroenterology and nutrition, 34(1), 59-62 (2001-12-26)
Biotinidase is the enzyme responsible for liberating the vitamin biotin from biocytin and dietary protein-bound vitamin. Individuals lacking biotinidase activity become biotin deficient. Because the liver is the major source of plasma biotinidase, chronic liver diseases can lead to decreased
Ahmaed Baashar et al.
The Journal of comparative neurology, 527(14), 2273-2290 (2019-03-13)
Descending auditory pathways can modify afferent auditory input en route to cortex. One component of these pathways is the olivocochlear system which originates in brainstem and terminates in cochlea. Medial olivocochlear (MOC) neurons also project collaterals to cochlear nucleus and
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