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A6339

Sigma-Aldrich

N-Acetyl-Val-Glu-Ile-Asp-al

~99% (HPLC), powder

Synonym(s):

Ac-VEID-CHO

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About This Item

Empirical Formula (Hill Notation):
C22H36N4O9
CAS Number:
319494-39-8
Molecular Weight:
500.54
MDL number:
MFCD01318861
UNSPSC Code:
12352209
PubChem Substance ID:
329770890
NACRES:
NA.32

Assay

~99% (HPLC)

Quality Level

200

form

powder

color

white

solubility

H2O: 1 mg/mL

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N[C@@H](CC(O)=O)C=O

InChI

1S/C22H36N4O9/c1-6-12(4)19(22(35)24-14(10-27)9-17(31)32)26-20(33)15(7-8-16(29)30)25-21(34)18(11(2)3)23-13(5)28/h10-12,14-15,18-19H,6-9H2,1-5H3,(H,23,28)(H,24,35)(H,25,34)(H,26,33)(H,29,30)(H,31,32)/t12-,14-,15-,18-,19-/m0/s1

InChI key

KYUFGGNCJRWMDN-GOYXDOSHSA-N

Gene Information

human ... CASP6(839)

Amino Acid Sequence

NAc-Val-Glu-Ile-Asp-al

Biochem/physiol Actions

Caspase 6 inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Callinice D Capo-chichi et al.
Molecular and cellular biology, 29(17), 4766-4777 (2009-07-08)
A prominent hallmark of most human cancer is aneuploidy, which is a result of the chromosomal instability of cancer cells and is thought to contribute to the initiation and progression of most carcinomas. The developmentally regulated GATA6 transcription factor is
Roman E Beloshistov et al.
The New phytologist, 218(3), 1167-1178 (2017-04-14)
Peptide hormones are implicated in many important aspects of plant life and are usually synthesized as precursor proteins. In contrast to animals, data for plant peptide hormone maturation are scarce and the specificity of processing enzyme(s) is largely unknown. Here
Ali Khoshnan et al.
PloS one, 4(6), e5768-e5768 (2009-06-03)
Proteolysis of huntingtin (Htt) plays a key role in the pathogenesis of Huntington's disease (HD). However, the environmental cues and signaling pathways that regulate Htt proteolysis are poorly understood. One stimulus may be the DNA damage that accumulates in neurons
Gustavo Lemos Rocha et al.
Plant science : an international journal of experimental plant biology, 288, 110232-110232 (2019-09-16)
Seed coat is the tissue which establishes an interface between the seed inner tissues and external environment. Our group has shown that cowpea seed coat undergoes coordinated events of programmed cell death (PCD) during development. In relation to germinating seed
Dagmar E Ehrnhoefer et al.
PloS one, 6(11), e27680-e27680 (2011-12-06)
Aberrant activation of caspase-6 has recently emerged as a major contributor to the pathogeneses of neurodegenerative disorders such as Alzheimer's and Huntington disease. Commercially available assays to measure caspase-6 activity commonly use the VEID peptide as a substrate. However these

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