A3418
Anti-α1-Acid Glycoprotein antibody produced in goat
whole antiserum
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About This Item
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biological source
goat
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
mol wt
antigen 40.8 kDa (sedimentation velocity and diffusion studies)
contains
15 mM sodium azide
species reactivity
human
technique(s)
quantitative precipitin assay: 1.5 mg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ORM1(5004)
General description
α-1 acid glycoprotein is a protein at 43kDa secreted mainly from the liver during acute phase reaction. Its expression is induced by cytokines and corticosteroids.
Alpha-1-acid glycoprotein (AGP) is also known as orosomucoid (ORM). It is a 41-43 kDa glycoprotein. It is one of the important acute phase proteins found in humans, rats, mice and other species. This immunosuppressive glycoprotein is composed of two isoforms, such as ORM1 and ORM2.
Goat Anti-α1-Acid Glycoprotein antibody is immunospecific for human α1-acid glycoprotein by immunoelectrophoresis versus human serum and α1-acid glycoprotein.
Immunogen
purified human α1-acid glycoprotein
Application
Goat Anti-α1-Acid Glycoprotein antibody can be used for quantitative precipitin assays at 1.5mg/ml.
Biochem/physiol Actions
Abberations of orosomucoid 1 (ORM1) is linked with the pharmacokinetics of telmisartan. This plasma protein participates in the binding and transport of several drugs.
Physical form
Supplied as a liquid containing 15mM sodium azide as preservative.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Effect of alpha-1-acid glycoprotein binding on pharmacokinetics and pharmacodynamics
Huang Z, et al.
Current Drug Metabolism, 14(2), 226-238 (2013)
P A Charlwood et al.
Biochimica et biophysica acta, 453(1), 81-92 (1976-11-26)
We have isolated from the plasma of man, rabbit, pig, rat and chicken alpha 1-acid glycoproteins that show a single band on polyacrylamide gel electrophoresis and a single arc in immunodiffusion. Amino acid and carbohydrate compositions are presented. The human
K Kostner et al.
Clinica chimica acta; international journal of clinical chemistry, 304(1-2), 29-37 (2001-02-13)
The atherogenic lipoprotein Lp(a) consists of an LDL-like core and apo(a), linked to apoB via a thiol bridge. Apo(a) fragments ranging in size from 60 to 220 kDa are excreted into urine and the excretion rate correlates significantly with the
Polymorphism of ORM1 Is Associated with the Pharmacokinetics of Telmisartan
Chen WQ, et al.
PLoS ONE, 8(8) (2013)
Polymorphism of ORM1 Is Associated with the Pharmacokinetics of Telmisartan
Chen WQ, et al.
Testing, 8(8) (2013)
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