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104R-1

Sigma-Aldrich

CD4 (SP35) Rabbit Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

SP35, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (104R-14)
vial of 0.5 mL concentrate (104R-15)
bottle of 1.0 mL predilute (104R-17)
vial of 1.0 mL concentrate (104R-16)
bottle of 7.0 mL predilute (104R-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, membranous

Gene Information

human ... CD4(920)

General description

CD4 is a 55-kD glycoprotein expressed on the surface of T-helper/regulatory T-cells,monocytes, macrophages, and some dendritic cells. The majority of peripheral T-celllymphomas are derived from the T-helper/regulatory cell subset so most matureT-cell neoplasms are CD4+. Anti-CD4 is used to identify normal T-cells and to aid in theidentification of neoplasms of T-cell origin.

Quality


IVD
IVD
IVD
RUO

Linkage

CD4 Positive Control Slides, Product No. 104S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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Cynthia Lehe et al.
Cancer research, 68(15), 6350-6359 (2008-08-05)
Compelling evidences indicate a key role for regulatory T cells (T(reg)) on the host response to cancer. The Wilms' tumor antigen (WT1) is overexpressed in several human leukemias and thus considered as promising target for development of leukemia vaccine. However
Manual of Diagnostic Antibodies for Immunohistology (2003)
Adriana Garcia-Herrera et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 26(20), 3364-3371 (2008-06-11)
To define the clinical and pathologic characteristics of primary cutaneous small/medium CD4(+) T-cell lymphoma (PCSM-TCL) and identify parameters of prognostic significance. We have investigated 24 patients with primary cutaneous lymphomas composed of small/medium mature T-cells with a betaF1, CD3, CD4(+)
Takashi Akiyama et al.
Pathology international, 58(10), 626-634 (2008-09-20)
The present study reports five CD8+, CD56+ (natural killer (NK)-like) T-cell lymphomas involving the small intestine without evidence of enteropathy, from Japan. Three were intestinal T-cell lymphoma. The site of origin of the other two was not definitive. Four of

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