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Y0000398

Methyl nicotinate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Nicotinic acid methyl ester

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About This Item

Empirical Formula (Hill Notation):
C7H7NO2
CAS Number:
Molecular Weight:
137.14
Beilstein:
113951
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

Agency

EP

API family

methyl nicotinate

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

bp

204 °C (lit.)

mp

42-44 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

COC(=O)c1cccnc1

InChI

1S/C7H7NO2/c1-10-7(9)6-3-2-4-8-5-6/h2-5H,1H3

InChI key

YNBADRVTZLEFNH-UHFFFAOYSA-N

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General description

Methyl nicotinate is a potent vasodilatory drug capable of transdermal penetration. It is known to elicit distinctive erythema through the production of prostaglandin D2(PGD2) and beneficial for the treatment of respiratory, vascular and rheumatoid disorders.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Methyl nicotinate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


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Delayed vasodilatory response to methylnicotinate in patients with unipolar depressive disorder
Ross BM, et al.
Journal of Affective Disorders, 82(2), 285-290 (2004)
Identification and quantification of methyl nicotinate in rice (Oryza sativa L.) by gas chromatography-mass spectrometry
RB Muralidhara, et al.
Food Chemistry, 105(2), 736-741 (2007)
Penny N Newson et al.
Behavioural brain research, 272, 55-65 (2014-07-01)
Treatment of neonatal rats with the transient receptor potential vanilloid 1 (TRPV1) channel agonist, capsaicin, produces life-long loss of sensory neurons expressing TRPV1 channels. Previously it was shown that rats treated on day 2 of life with capsaicin had behavioural
Stéphanie Romand et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 14-21 (2014-07-06)
A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) were compared: (i) a hydroxypropylcellulose (HPC) coated capillary in aqueous medium and

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