BCR312
2-Nitro-7-methoxynaphtho[2,1-b]furan
BCR®, certified reference material
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About This Item
Empirical Formula (Hill Notation):
C13H9NO4
CAS Number:
Molecular Weight:
243.21
Beilstein:
5749492
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
grade
certified reference material
Agency
BCR®
manufacturer/tradename
JRC
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
format
neat
storage temp.
2-8°C
SMILES string
COc1ccc2c(ccc3oc(cc23)[N+]([O-])=O)c1
InChI
1S/C13H9NO4/c1-17-9-3-4-10-8(6-9)2-5-12-11(10)7-13(18-12)14(15)16/h2-7H,1H3
InChI key
BRRIJZQYTOFDAF-UHFFFAOYSA-N
Analysis Note
For more information please see:
BCR312
BCR312
Legal Information
BCR is a registered trademark of European Commission
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Muta. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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P Quillardet et al.
Mutation research, 358(1), 113-122 (1996-10-28)
The influence of the uvr-dependent excision repair system on the lethal action, mutagenic specificity, SOS induction and DNA adducts formation of 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000), a potent genotoxic nitrofuran, were examined in Escherichia coli. Binding measurements of 3H-labelled R7000 to DNA indicated
L Cui et al.
Cancer letters, 76(2-3), 161-166 (1994-01-30)
Among the nitro-naphthofurans, 7-methoxy-2-nitro-naphtho[2,1-b]furan (R7000) has proved to be a very potent mutagen that causes sarcomas at the subcutaneous injection site and carcinomas in the forestomach after p.o. administration. In the present study, possible promoting activity for diethylnitrosamine (200 mg/kg
R J Salmon et al.
Cancer letters, 35(1), 59-64 (1987-04-01)
7-Methoxy-2-nitro-naphtho[2,1-b]furan (R 7000) and its methylated homolog in position 1 (R 7372) are among the most mutagenic agents presently known, as shown by the results obtained both in the Ames test and in the SOS Chromotest. Their carcinogenic effects were
H Strapélias et al.
Carcinogenesis, 9(11), 1987-1993 (1988-11-01)
The metabolism of 7-methoxy-2-nitro-naphtho[2,1-b]furan and the subsequent binding to DNA, under aerobic conditions, were investigated using liver microsomes of both untreated rats and rats pre-treated with 3-methylcholanthrene [3-MC]. The metabolites were analyzed by HPLC. The following compounds: 7-hydroxy-2-nitro-naphtho[2,1-b]-furan-6,9-dione; 6,7-dihydro-2-nitro-naphtho[2,1-b]furan; 7-hydroxy-2-nitro-naphtho[2,1-b]furan
[In vitro antibacterial activity of 7-methoxy-2-nitronaphto [2,1-b]furan (R 7000)].
A Amgar et al.
Annales pharmaceutiques francaises, 41(3), 283-285 (1983-01-01)
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