917354
tert-Butyl 4-(4-(aminomethyl)phenyl)piperidine-1-carboxylate
Synonym(s):
Semi-flexible linker for PROTAC® development
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About This Item
Empirical Formula (Hill Notation):
C17H26N2O2
CAS Number:
Molecular Weight:
290.40
MDL number:
UNSPSC Code:
12352200
Recommended Products
form
powder
Quality Level
reaction suitability
reagent type: linker
functional group
Boc
amine
storage temp.
2-8°C
SMILES string
O=C(N(CC1)CCC1C(C=C2)=CC=C2CN)OC(C)(C)C
Application
tert-Butyl 4-(4-(aminomethyl)phenyl)piperidine-1-carboxylate is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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