402885

p-Toluenesulfonic acid monohydrate

ACS reagent, ≥98.5%

• Synonym(s): 4-Methylbenzenesulfonic acid monohydrate, 4-Toluenesulfonic acid monohydrate, PTSA monohydrate, TsOH monohydrate
• Linear Formula: CH₃C₆H₄SO₃H · H₂O
• CAS Number: 6192-52-5
• Molecular Weight: 190.22
• Beilstein: 3568023
• EC Number: 203-180-0
• MDL number: MFCD00142137
• UNSPSC Code: 12352100
• PubChem Substance ID: 24865132
• NACRES: NA.21

Properties

• grade: ACS reagent
• Quality Level: 200
• vapor density: 5.9 (vs air)
• Assay: ≥98.5%
• form: solid
• clarity of soln: passes test
• impurities: 9.5-11.5% water
• ign. residue: ≤0.1%
• mp: 103-106 °C (lit.)
• solubility: H₂O: 10g + 50 mL, clear, colorless
• anion traces: sulfate (SO₄^2-): ≤0.3%
• cation traces: Fe: ≤0.01%; Na: ≤0.002%; heavy metals (as Pb): ≤0.001%
• SMILES string: [H]O[H].Cc1ccc(cc1)S(O)(=O)=O
• InChI: 1S/C7H8O3S.H2O/c1-6-2-4-7(5-3-6)11(8,9)10;/h2-5H,1H3,(H,8,9,10);1H2
• InChI key: KJIFKLIQANRMOU-UHFFFAOYSA-N

Description

General description

p-Toluenesulfonic acid monohydrate, an oxonium salt, is an inexpensive and easy to handle organic catalyst used in organic synthesis. The study of its crystalline structure shows that it is monoclinic with P2₁/c space group. Its solubility in aqueous sulfuric acid solutions has been studied.

Application

p-Toluenesulfonic acid monohydrate (p-TsOH·H₂O) may be used as a catalyst in the synthesis of the following:

• Unsymmetrical benzils.
• Highly substituted piperidines.
• 1,3,5-Trisubstituted benzenes by trimerization of alkynes.
• Triazoloquinazolinone and benzimidazoquinazolinone derivatives.
• 1,3,5-Trisubstituted pyrazoles derivatives.
• Selenated ketene dithioacetals.

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H290 - H314 - H335 - H412
• Precautionary Statements: P234 - P260 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Aquatic Chronic 3 - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1C - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 8A - Combustible, corrosive hazardous materials
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves