SCT090

BioTracker Bacterial FtsZ Live Cell Dye

• Synonym(s): BioTracker Bacterial FtsZ Live Cell Dye
• UNSPSC Code: 12352207

Properties

• form: lyophilized
• mol wt: calculated mol wt 782.1
• packaging: pkg of 1 mg
• manufacturer/tradename: Millipore
• storage condition: protect from light
• growth mode: N/A
• shipped in: ambient
• storage temp.: −20°C

Description

General description

The filamentous temperature-sensitive Z (FtsZ) protein is a promising target for the development of new antibacterial drug targets. FtsZ is a protein encoded by the ftsZ gene that assembles into a ring at the future site of bacterial cell division and is one of the most conserved proteins in prokaryotes. This live cell probe will aid development of new FtsZ inhibitors and enable screening for FtsZ inhibition in a broad range of bacterial species. BioTracker Bacterial FtsZ Live Cell Dye is a BODIPY conjugated fluorescent probe that binds FtsZ proteins from both Gram-positive pathogens (Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Streptococcus pyogenes, Streptococcus agalactiae, and Streptococcus pneumoniae) and Gram-negative pathogens (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii) (1). It allows for visualization of FtsZ using fluorescence microscopy, and can be used to monitor and identify non-fluorescent FtsZ inhibitors in these target pathogens. Spectral PropertiesExcitation: 488 nmEmission: 510 nmReference:1. Ferrer-González, Edgar, et al. "Structure-Guided Design of a fluorescent probe for the Visualization of ftsZ in clinically important Gram-positive and Gram-negative Bacterial pathogens." Scientific reports 9.1 (2019): 1-16.

Application

Purity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.

Features and Benefits

Fluorescence probe for detecting FtsZ in bacteria

Physical form

Lyophilized. Red solid.

Storage and Stability

Store at -20°C, desiccate and protect from light.
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable