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Key Documents

ABS535

Sigma-Aldrich

Anti-Arginase-1 Antibody

from chicken

Synonym(s):

Type 1 Arginase

ARG1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

chicken

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

guinea pig, human, mouse, rat

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgY

NCBI accession no.

NP_058830

UniProt accession no.

P07824

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ARG1(383)
mouse ... Arg1(11846)
rat ... Arg1(29221)

General description

Arginase-1, the protein encoded by the ARG1 gene, is the enzyme that catalyzes the breakdown of L-arginine into ornithine and urea. ARG1 is a key player in the Urea cycle. There are two distinct isoforms of Arginase, Arginase I and Arginase II. Arginase I (also called the liver type arginase or Type 1 arginase) is a highly expressed cytosolic enzyme in the liver and other tissues, including the brain. Arginase II or kidney-type arginase is also widely expressed at low levels in many tissues but localized to the mitochondria primarily. Interestingly, Arginase 1 has neuroprotective properties. Arginase I is essential for protecting motor neurons from nitric oxide dependent apoptosis that can be induced upon cellular stress or trophic factor removal. By suppressing nitric oxide production, Arginase prevents the formation of peroxynitrite and its subsequent cellular toxicity. Furthermore, Arginase 1 appears to play critical roles throughout the CNS for survival and regeneration of neurons and axons. In cancer, Arginase 1, already a useful marker for hepatocytes is also an excellent marker for hepatocellular cancers.

Immunogen

Full-length recombinant protein corresponding to Rat Arginase-1.

Application

Immunohistochemistry Analysis: A representative lot detected Arginase-1 in bronchoalveolar lavage cells (Zimmermann, N., et al. (2003). J. Clin. Invest. 111:1863–1874 (2003)).
Western Blotting Analysis: A representative lot detected Arginase-1 in RAW cell lysate (Morris, S., et al. (1998). Am J Physiol Endocrinol Metab 275:E740-E747, 1998).
Research Category
Signaling
This Anti-Arginase-1 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of Arginase-1.

Quality

Evaluated by Western Blotting in mouse LN tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected Arginase-1 in 10 µg of mouse LN tissue lysate.

Target description

~ 38 kDa observed

Physical form

Format: Purified
IgY purified from Yolk
Purified chicken Polyclonal other in buffer containing PBS with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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