AB9690
Anti-NMDAR2B phospho Tyrosine 1336 Antibody
Chemicon®, from rabbit
Synonym(s):
NR2B
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
phosphorylation (pTyr1336)
Gene Information
rat ... Grin2B(24410)
Specificity
NMDAR2B, phosphoTyrosine1336. The antibody recognizes a protein of ~180 kDa corresponding to NMDAR2B, phosphoTyrosine1336 in lysates from rat brain hippocampus. Immunolabeling is blocked by the phosphopeptide used as the immunogen but not the corresponding non-phosphopeptide. Immunolabeling is also blocked by l-phosphatase treatment.
Immunogen
Synthetic peptide of amino acids surrounding the phosphoTyrosine 1336 site of rat NMDAR2B. The immunogen has 100% similarity with human and mouse.
Application
Detect NMDAR2B phospho Tyrosine 1336 using this Anti-NMDAR2B phospho Tyrosine 1336 Antibody validated for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neurotransmitters & Receptors
Western blot: 1:1,000.
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Linkage
Replaces: 07-533
Physical form
Affinity purified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
Storage and Stability
Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity.
Carroll, Reed C and Zukin, R Suzanne
Trends in Neurosciences, 25, 571-577 (2002)
D R Grosshans et al.
Nature neuroscience, 5(1), 27-33 (2001-12-12)
In the CA1 region of the rat hippocampus, long-term potentiation (LTP) requires the activation of NMDA receptors (NMDARs) and leads to an enhancement of AMPA receptor (AMPAR) function. In neonatal hippocampus, this increase in synaptic strength seems to be mediated
Jérémy Ferrier et al.
PloS one, 8(10), e77828-e77828 (2013-11-10)
Oxaliplatin is an anticancer drug used for the treatment of advanced colorectal cancer, but it can also cause painful peripheral neuropathies. The pathophysiology of these neuropathies has not been yet fully elucidated, but may involve spinal N-methyl-D-aspartate (NMDA) receptors, particularly
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