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Key Documents

AB1518

Sigma-Aldrich

Anti-Neurofibrillary Tangles Antibody

serum, Chemicon®

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

shipped in

dry ice

target post-translational modification

unmodified

Related Categories

Specificity

Specifically stains neurofibrillary tangles and degenerating plaque neurites in cases of Alzheimer′s disease, Down′s Syndrome and normal aged individuals.

Immunogen

Neurofibrillary tangles which were extracted in boiling SDS and purified by sucrose gradient centrifugation.

Application

Anti-Neurofibrillary Tangles Antibody is an antibody against Neurofibrillary Tangles for use in ELISA, WB, IH, IH(P).
Immunohistochemistry on paraffin, vibratome and frozen sections: ≥1:200, ≥1:2,000, respectively.

Western blotting: ≥1:500.

ELISA using immunogen peptide: ≥1:4,000.

Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases

Physical form

Rabbit antisera with 0.01% thimerosal.

Storage and Stability

Store at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alzheimer paired helical filaments: immunochemical identification of polypeptides.
Grundke-Iqbal, I, et al.
Acta neuropathologica, 62, 259-267 (1984)
Rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signaling.
Suo, Z; Wu, M; Citron, BA; Palazzo, RE; Festoff, BW
The Journal of Biological Chemistry null
Comparative analysis of an improved thioflavin-s stain, Gallyas silver stain, and immunohistochemistry for neurofibrillary tangle demonstration on the same sections.
Anyang Sun, Xuan V Nguyen, Guoying Bing
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society null
Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
Wang, HY; Bakshi, K; Frankfurt, M; Stucky, A; Goberdhan, M; Shah, SM; Burns, LH
The Journal of Neuroscience null
Anti-PHF antibodies: an immunohistochemical marker of the lesions of the Alzheimer's disease. Characterization and comparison with Bodian's silver impregnation.
Persuy, P, et al.
Virchows Archiv. A, Pathological Anatomy and Histopathology, 407, 13-23 (1985)

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