8.55140

Fmoc-PAL-Linker

Novabiochem^®

• Synonym(s): Fmoc-PAL-Linker
• Empirical Formula (Hill Notation): C₂₉H₃₁NO₇
• CAS Number: 115109-65-4
• Molecular Weight: 505.56
• UNSPSC Code: 12352209
• NACRES: NA.22

Properties

• Quality Level: 200
• product line: Novabiochem^®
• form: solid
• reaction suitability: reagent type: linker
• manufacturer/tradename: Novabiochem^®
• mp: 178-180 °C
• application(s): peptide synthesis
• functional group: Fmoc
• storage temp.: 2-8°C
• InChI: 1S/C29H31NO7/c1-34-26-15-19(36-14-8-7-13-28(31)32)16-27(35-2)24(26)17-30-29(33)37-18-25-22-11-5-3-9-20(22)21-10-4-6-12-23(21)25/h3-6,9-12,15-16,25H,7-8,13-14,17-18H2,1-2H3,(H,30,33)(H,31,32)
• InChI key: ATYUCXIJDKHOPX-UHFFFAOYSA-N

Description

General description

Barany′s aminomethyl-dimethoxyphenoxyvaleric acid linker ^[1]. The amino group of this linker can be easily acylated under standard coupling conditions. Following peptide assembly, treatment with 95% TFA containing scavengers releases the desired peptide amide. Studies have shown the acid sensitivity of this linker to be around twice that of the Rink amide linker ^[2]. There is some evidence to suggest that PAL resins give greater yields in microwave assisted synthesis.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Analysis Note

Color (visual): white to beige to grey
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(0811)): ≥ 98.0 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable