5.05894

CGP 7930

• Synonym(s): CGP 7930, GABA B Receptor Antagonist, CGP7930, CGP 7930, CGP-7930
• Empirical Formula (Hill Notation): C₁₉H₃₂O₂
• CAS Number: 57717-80-3
• Molecular Weight: 292.46
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: pale yellow
• solubility: DMSO: 100 mM; ethanol: 100 mM
• storage temp.: 2-8°C
• InChI: 1S/C19H32O2/c1-17(2,3)14-9-13(11-19(7,8)12-20)10-15(16(14)21)18(4,5)6/h9-10,20-21H,11-12H2,1-8H3
• InChI key: XLWJPQQFJNGUPA-UHFFFAOYSA-N

Description

General description

A blood brain barrier permeable, positive allosteric modulator of the metabotropic GABA_B receptor. Shown to modulate GABA_B receptor in the high affinity state and thereby increases agonist affinity for the receptor. Also enhances agonist potency and efficacy even on recombinant GABA_B receptors. Exhibits anxiolytic effects in rodents.

Warning

Toxicity: Standard Handling (A)

Other Notes

Adams, C. et al., 2007. CNS Drug Rev.13, 308.
Pin, J.P., et al., 2007. Curr. Neuropharmacol.5, 195.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable