475914

Nystatin, Streptomyces noursei

A polyene antifungal antibiotic effective against yeast and mycoplasma.

• Synonym(s): Nystatin, Streptomyces noursei, Mycostatin
• Empirical Formula (Hill Notation): C₄₇H₇₅NO₁₇
• CAS Number: 1400-61-9
• Molecular Weight: 926.09
• MDL number: MFCD25541651
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (sum of two peaks, HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white to yellow
• solubility: DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31?,32?,33?,34?,35?,36?,37?,38?,40?,41-,42+,43+,44-,46+,47+/m0/s1
• InChI key: VQOXZBDYSJBXMA-RKEBNKJGSA-N

Description

General description

A polyene antifungal antibiotic effective against yeast and mycoplasma. Induces loss of low molecular weight substances from cells with low selectivity. A cation selective ionophore that exhibits selectivity for Na⁺. Increases the activity of the Na⁺-K⁺ pump. Suggested concentration is 50 µg/ml.

A polyene antifungal antibiotic effective against yeast and mycoplasma. Induces loss of low molecular weight substances from cells with low selectivity. A cation-selective ionophore that exhibits selectivity for Na⁺. Increases the activity of Na⁺ - K⁺ pump.

Biochem/physiol Actions

Potency: ≥3000 units/mg (anhydrous).

Warning

Toxicity: Standard Handling (A)

Other Notes

Gruwel, M.L., et al. 1995. Am J. Physiol.268, H351.
Opekarova, M., and Tanner, W. 1994. FEBS Lett. 360, 46.
Stoos, B.A., et al. 1994. J. Am. Soc. Nephrol.4, 1855.
Skolink, P.R., et al. 1989. J. Infect. Dis.160, 1056.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable