218728
Caspase-9 Inhibitor III
The Caspase-9 Inhibitor III, also referenced under CAS 403848-57-7, controls the biological activity of Caspase-9. This small molecule/inhibitor is primarily used for Cancer applications.
Synonym(s):
Caspase-9 Inhibitor III, Ac-LEHD-CMK
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About This Item
Empirical Formula (Hill Notation):
C24H35ClN6O9
CAS Number:
Molecular Weight:
587.02
UNSPSC Code:
12352200
NACRES:
NA.54
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Quality Level
Assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
color
white
solubility
water: 1 mg/mL
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A potent and irreversible inhibitor of caspase-9 (ICE-LAP6, Mch6). Reported to reduce myocardial infarct size during reperfusion (~70 nM).
A potent, irreversible inhibitor of caspase-9. Reported to reduce myocardial infarct size during reperfusion (~70 nM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
caspase-9
caspase-9
Product does not compete with ATP.
Reversible: no
Target IC50: 70 nM against caspase-9
Warning
Toxicity: Standard Handling (A)
Sequence
Ac-Leu-Glu-His-Asp-CMK
Other Notes
Mocanu, M.M., et al. 2000. Br. J. Pharmacol.130, 197.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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