1.06529

Sodium polyphosphate

(Graham′s salt) EMPLURA^®

• Synonym(s): Sodium polyphosphate, Graham′s salt, Sodium metaphosphate
• Linear Formula: (NaPO₃)_n
• CAS Number: 10361-03-2
• MDL number: MFCD00131858
• UNSPSC Code: 12352302
• EC Index Number: 233-782-9
• NACRES: NA.21

Properties

• Quality Level: 200
• product line: EMPLURA^®
• form: solid
• potency: >2000 mg/kg LD₅₀, oral (Rat)
• concentration: ≥68% ( P₂O₅, acidimetric)
• pH: 5.7 (20 °C, 10 g/L in H₂O)
• mp: 550 °C
• solubility: 1000 g/L
• density: 2.5 g/cm³ at 20 °C
• bulk density: 1000 kg/m³
• anion traces: chloride (Cl^-): ≤0.02%
• cation traces: Fe: ≤0.01%; heavy metals (as Pb): ≤0.005%
• storage temp.: 2-30°C
• InChI: 1S/Na.HO3P/c;1-4(2)3/h;(H,1,2,3)/q+1;/p-1
• InChI key: AQMNWCRSESPIJM-UHFFFAOYSA-M

Description

Application

• Novel method for the preparation of controlled-release theophylline granules coated with a polyelectrolyte complex of sodium polyphosphate-chitosan.: This paper presents a novel approach to creating controlled-release theophylline granules using a coating made from a polyelectrolyte complex of sodium polyphosphate and chitosan. This method could significantly impact pharmaceutical formulations by improving drug release profiles and patient compliance (Kawashima et al., 1985).

Analysis Note

Assay (acidimetric, P₂O₅): ≥ 68 %
Identity: passes test
Chloride (Cl): ≤ 0.02 %
Heavy metals (as Pb): ≤ 0.005 %
Fe (Iron): ≤ 0.01 %

Legal Information

EMPLURA is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable