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Key Documents

1.04877

Supelco

Potassium phosphate monobasic

for analysis (<= 0.005% Na) EMSURE® ACS,ISO,Reag. Ph Eur

Synonym(s):

Potassium phosphate monobasic, Potassium dihydrogen phosphate, mono-Potassium orthophosphate, Potassium biphosphate, Potassium phosphate monobasic, Monopotassium phosphate, prim.-Potassium phosphate

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About This Item

Linear Formula:
KH2PO4
CAS Number:
Molecular Weight:
136.09
MDL number:
UNSPSC Code:
12352302
EC Index Number:
231-913-4
NACRES:
NA.21

grade

ACS reagent

Quality Level

Agency

reag. ISO
reag. Ph. Eur.

product line

EMSURE®

Assay

≥99.0% dry basis (alkalimetric)
98.0-100.5% (alkalimetric)

form

solid

potency

>4640 mg/kg LD50, skin (Rabbit)

impurities

≤0.01% Insoluble matter

loss

≤ 0.2% loss on drying, 130 °C

pH

4.2-4.6 (20 °C, 20 g/L in H2O)

mp

252.6 °C (lit.)

density

2.338 g/mL at 25 °C (lit.)

bulk density

1200 kg/m3

anion traces

chloride (Cl-): ≤0.0005%
sulfate (SO42-): ≤0.003%

cation traces

As: ≤0.0002%
Fe: ≤0.0010%
N: ≤0.001%
Na: ≤0.005%
heavy metals: ≤0.001%
heavy metals (as Pb): ≤0.0010%

storage temp.

2-30°C

SMILES string

[K+].OP(O)([O-])=O

InChI

1S/K.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+1;/p-1

InChI key

GNSKLFRGEWLPPA-UHFFFAOYSA-M

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Application


  • β-lactoglobulin stabilized nanemulsions--Formulation and process factors affecting droplet size and nanoemulsion stability.: This research explores the stabilization mechanisms of β-lactoglobulin in nanemulsions, with implications for pharmaceutical and food sciences, potentially utilizing substances like potassium phosphate monobasic for stability and pH control (Ali et al., 2016).


Analysis Note

Assay (alkalimetric): ≥ 99.0 %
Assay (alkalimetric, calculated on dried substance): 98.0 - 100.5 %
Assay (alkalimetric; dried substance): ≥ 99.5 %
Identity: passes test
Appearance of solution: passes test
Insoluble matter: ≤ 0.01 %
pH-value (5 %; water, 25 °C): 4.2 - 4.5
Chloride (Cl): ≤ 0.0005 %
Sulfate (SO₄): ≤ 0.003 %
Total nitrogen (N): ≤ 0.001 %
Heavy metals (as Pb): ≤ 0.0010 %
Heavy metals (ACS): ≤ 0.001 %
As (Arsenic): ≤ 0.0002 %
Fe (Iron): ≤ 0.0010 %
Na (Sodium): ≤ 0.005 %
Reducing substances: passes test
Loss on drying (130 °C): ≤ 0.2 %
Corresponds to ACS,ISO,Reag. Ph Eur

Legal Information

EMSURE is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Protocols

A simple, precise and sensitive Reverse-Phase High Pressure Liquid Chromatography gradient method was adapted for traceability, homogeneity and total chromatographic analysis of Dexamethasone. The given experimental conditions follow the USP43-NF38 monograph method for Dexamethasone Assay and Organic Impurity Profiling. Dexamethasone, Betamethasone, Dexamethasone acetate and Desoximetasone were baseline resolved within 20 minutes using a Titan C18 UHPLC column (2.1 x 100 mm, 1.9 µm).

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