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07-817

Sigma-Aldrich

Anti-phospho-Glycogen Synthase(Ser641/Ser645) Antibody

Upstate®, from rabbit

Synonym(s):

Glycogen synthase 1, GYS1, GS

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, mouse

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_002103.3

UniProt accession no.

P13807

shipped in

dry ice

target post-translational modification

phosphorylation (pSer641/pSer645)

Gene Information

human ... GYS1(2997)

Specificity

Glycogen Synthase phosphorylated on serine residues 641 and 645
Predicted to cross-react with rat based on sequence homology (100%), but have not been tested.

Immunogen

Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-Glycogen Synthase (Ser641/Ser645).

Application

Anti-phospho-Glycogen Synthase(Ser641/Ser645) Antibody is an antibody against phospho-Glycogen Synthase(Ser641/Ser645) for use in WB.
Research Sub Category
Insulin/Energy Signaling

PI3K, Akt, & mTOR Signaling

Quality

Routinely evaluated by immunoblot.

Target description

85 kDa

Physical form

Affinity purified rabbit polyclonal IgG in Dulbecco’s PBS, pH 7.3 with 1.0 mg/mL BSA, 0.05% sodium azide, and 50% glycerol.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Laura Marr et al.
Nature communications, 13(1), 3372-3372 (2022-06-12)
Glycogen is the major glucose reserve in eukaryotes, and defects in glycogen metabolism and structure lead to disease. Glycogenesis involves interaction of glycogenin (GN) with glycogen synthase (GS), where GS is activated by glucose-6-phosphate (G6P) and inactivated by phosphorylation. We
C T Shearn et al.
Biochemistry, 50(19), 3984-3996 (2011-03-29)
The production of reactive aldehydes such as 4-hydroxy-2-nonenal (4-HNE) is a key component of the pathogenesis in a spectrum of hepatic diseases involving oxidative stress such as alcoholic liver disease (ALD). One consequence of ALD is increased insulin resistance in
Cole D Davidson et al.
Journal of the Endocrine Society, 5(8), bvab102-bvab102 (2021-07-15)
Thyroid cancer is the most common endocrine malignancy, and the global incidence has increased rapidly over the past few decades. Anaplastic thyroid cancer (ATC) is highly aggressive, dedifferentiated, and patients have a median survival of fewer than 6 months. Oncogenic
Paras S Minhas et al.
Nature, 590(7844), 122-128 (2021-01-22)
Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty1-3. The ageing brain is also vulnerable to inflammation, as demonstrated by the high prevalence of age-associated cognitive decline and Alzheimer's disease4-6.

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