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Key Documents

06-1385

Sigma-Aldrich

Anti-PDX1 (goat) Antibody

serum, from goat

Synonym(s):

pancreatic and duodenal homeobox 1, pancreatic-duodenal homeobox factor 1, somatostatin transcription factor 1, insulin promoter factor 1, homeodomain transcription factor, Insulin promoter factor 1, Somatostatin-transactivating factor 1, Insulin upstrea

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

goat

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_032840

UniProt accession no.

P52946

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Pdx1(18609)

General description

Transcription factor PDX1, also known as pancreatic and duodenal homeobox 1, activates expression of the insulin and somatostatin genes. This protein is a key regulator of islet peptide hormone expression and also plays an essential role in pancreatic development. It has been shown to interact with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). This protein also interacts with the methyltransferase SETD7. Mutations in this gene may be involved in several disorders of the pancreas or in diabetes mellitus.

Immunogen

Recombinant protein corresponding to the N-terminus of mouse PDX1.

Application

Anti-PDX1 (goat) Antibody is a Goat Polyclonal Antibody for detection of PDX1 also known as pancreatic & duodenal homeobox 1, somatostatin transcription factor 1, Insulin promoter factor 1 & has been validated in WB & IHC.
Immunohistochemistry Analysis: 1:400 dilution from a represenative lot detected PDX1 in normal human pancreas tissue.

Quality

Evaluated by Western Blot in mouse pancreatic β T-cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected PDX1 on 10 µg of mouse pancreatic β T-cell lysate.

Target description

~ 39 kDa

Physical form

Unpurified goat polyclonal serum containing 0.05% sodium azide.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

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