V-029

Valproic Acid-D₆ solution

1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Synonym(s): Valproic Acid-D₆ solution
• Empirical Formula (Hill Notation): C₈H₁₀D₆O₂
• CAS Number: 87745-18-4
• Molecular Weight: 150.25
• EC Number: 200-659-6
• MDL number: MFCD01074058
• UNSPSC Code: 41116107
• PubChem Substance ID: 329828970
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: (Snap-N-Spike^®)
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 1 mg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• SMILES string: OC(C(CCC([2H])([2H])[2H])CCC([2H])([2H])[2H])=O
• InChI: 1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)/i1D3,2D3
• InChI key: NIJJYAXOARWZEE-WFGJKAKNSA-N

Description

General description

An internal standard and Certified Spiking Solution^® suitable for quantitation of valproic acid levels in urine or other matrices by LC/MS or GC/MS for testing applications in clinical toxicology, forensic analysis, medication monitoring, urine drug testing, or therapeutic drug monitoring. Valproic acid, sold under trade names such as Depakote^®, Valparin, or Stavzor^®, is an antiepileptic drug and mood stabilizer. The drug is prescribed for treatment of epilepsy, bipolar disorder, migraine headaches, and depression.

Application

• Catalysis driven by an amyloid-substrate complex: Research demonstrates the role of buffer concentrates in maintaining optimal pH and stability conditions during biochemical reactions involving amyloid substrates, critical for developing new therapeutic agents (Sawazaki et al., 2024).


• High throughput microfluidics-based synthesis of PEGylated liposomes for precise size control and efficient drug encapsulation: This research utilizes buffer concentrates to manage the pH and ionic strength during the microfluidic synthesis of PEGylated liposomes, critical for achieving size precision and high encapsulation efficiency in drug delivery systems (Akar et al., 2024).


• Development of Analytical Quality by Design RP-HPLC Method and Its Validation for Estimation of Gefitinib from Bulk, Tablet Dosage Form and Complex Nanoformulation: Buffer concentrates play a vital role in this study, optimizing the RP-HPLC method for precise quantification of gefitinib, a critical aspect in ensuring the quality and efficacy of pharmaceutical products (More et al., 2024).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Depakote is a registered trademark of Sanofi S.A.

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Stavzor is a registered trademark of Noven Therapeutics, LLC

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 49.5 °F
• Flash Point(C): 9.7 °C