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H-107

Supelco

1,25-Dihydroxyvitamin D3-13C3 (25,26,27-13C3) solution

5 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

Deuterated 1

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About This Item

Empirical Formula (Hill Notation):
13C3C24H44O3
Molecular Weight:
419.61
EC Number:
200-578-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

(Snap-N-Spike®)

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

5 μg/mL in ethanol

mp

-143.99 °C

application(s)

clinical testing
clinical testing

format

single component solution

storage temp.

−70°C

SMILES string

O[C@@H](C[C@H](O)C/1=C)CC1=C\C=C2[C@@](CC[C@]3([H])[C@H](C)CCC[13C](O)([13CH3])[13CH3])([H])[C@]3(C)CCC\2

InChI

1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1/i3+1,4+1,26+1

InChI key

GMRQFYUYWCNGIN-SYUIRNBGSA-N

General description

A stable-labeled internal standard suitable for quantitation of 1,25-Dihydroxyvitamin D3 levels by LC-MS/MS. 1,25-Dihydroxyvitamin D3, also known as calcitriol, is a hormonally active metabolite of vitamin D responsible for regulating calcium. Measurement of 1,25-Dihydroxyvitamin D3 is used to distinguish some cases of primary hyperparathyroidism from hypercalcemia of cancer and for the differential diagnosis of vitamin D-dependent rickets.

Application


  • Leigh Syndrome with HIBCH Mutations: Discusses the metabolic effects of mutations related to Leigh syndrome and includes information on 3-hydroxybutyryl carnitine isomers (Wang et al., 2021, frontiersin.org).

  • Highly Efficient Ketone Body Treatment in Leukodystrophy: Highlights the therapeutic potential of L-carnitine in treatments, specifically focusing on the metabolism of L-3-hydroxybutyryl-CoA in the context of fatty acid β-oxidation disorders (Gautschi et al., 2015, nature.com).

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

H-073

25-Hydroxyvitamin D2 solution, 50 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

H-074

D6-25-Hydroxyvitamin D3 (26,26,26,27,27,27-D6) solution, 50 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

H-083

25-Hydroxyvitamin D3 solution, 100 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

H-089

1α,25-Dihydroxyvitamin D3 solution, 5 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

H-090

1α,25-Dihydroxyvitamin D2 solution, 5 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

V-026

D3-Vitamin D2 (6,19,19-D3) solution, 100 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

V-025

Vitamin D3 solution, 1 mg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

V-024

Vitamin D2 solution, 1 mg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

H-162

1,24-Dihydroxyvitamin D3 solution, 50 μg/mL (Ethanol with 0.1%BHT (degassed)), certified reference material, ampule of 1 mL, Cerilliant®

H-160

24,25-Dihydroxyvitamin D3 solution, 50 μg/mL (Degassed Ethanol with 0.1% BHT), certified reference material, ampule of 1 mL, Cerilliant®

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Statements

H225,H319

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

57.2 °F - closed cup

Flash Point(C)

14.0 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Fang Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(26), 12986-12995 (2019-06-12)
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PloS one, 7(12), e53280-e53280 (2013-01-04)
Cyclodextrins are sugar compounds that are increasingly finding medicinal uses due to their ability to complex with hydrophobic molecules. One cyclodextrin in particular, 2-hydroxypropyl-β-cyclodextrin (HPβCD), is used as a carrier to solubilize lipophilic drugs and is itself being considered as
Benny Liu et al.
Journal of lipid research, 49(3), 663-669 (2007-12-14)
Niemann-Pick type C (NPC) disease is a multisystem disorder caused primarily by a mutation in the npc1 gene. These studies evaluated the effect of genetic background, deletion of additional genes, and administration of several agents on the age at death
Matthew B Pomrenze et al.
Cell reports, 29(1), 13-21 (2019-10-03)
Central amygdala (CeA) neurons that produce corticotropin-releasing factor (CRF) regulate anxiety and fear learning. These CeACRF neurons release GABA and several neuropeptides predicted to play important yet opposing roles in these behaviors. We dissected the relative roles of GABA, CRF
Caroline M Gorvin et al.
JCI insight, 2(3), e91103-e91103 (2017-02-15)
Heterozygous germline gain-of-function mutations of G-protein subunit α11 (Gα11), a signaling partner for the calcium-sensing receptor (CaSR), result in autosomal dominant hypocalcemia type 2 (ADH2). ADH2 may cause symptomatic hypocalcemia with low circulating parathyroid hormone (PTH) concentrations. Effective therapies for
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