D-927
Doxepin hydrochloride solution
1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Empirical Formula (Hill Notation):
C19H22ClNO
CAS Number:
Molecular Weight:
315.84
UNSPSC Code:
41116107
NACRES:
NA.24
Recommended Products
grade
certified reference material
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in methanol (as free base)
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
−20°C
SMILES string
CN(C)CC/C=C1C2=C(C=CC=C2)COC3=C/1C=CC=C3.[H]Cl
InChI
1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11-;
InChI key
MHNSPTUQQIYJOT-CULRIWENSA-N
General description
Doxepin is a tricyclic antidepressant used for the treatment of sleep maintenance and sold under trade names such as Silenor® and Aponal. This analytical reference standard is appropriate for use as starting material in calibrators or controls for numerous LC/MS or GC/MS applications such as forensic analysis, clinical toxicology, urine drug testing, or pharmaceutical research.
Application
- Magnetic Particle Spray Mass Spectrometry: This study utilizes advanced analytical techniques, potentially incorporating Doxepin hydrochloride as a standard in mass spectrometry, to improve detection sensitivities for antidepressants and other neuropharmacological agents (Venga Mendes and Figueiredo, 2024).
- Desipramine induces anti-inflammatory dorsal root ganglion transcriptional signatures: Though primarily about desipramine, the methodologies and findings could be paralleled in studies using Doxepin hydrochloride to understand its effects on neuroinflammation and pain management (Serafini et al., 2024).
- Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: Reviews the mitigation of toxicity from drugs like Doxepin hydrochloride, underscoring the importance of lipid emulsions in treating drug overdoses and adverse effects (Hwang and Sohn, 2024).
- Novel Ti surface coated with PVA hydrogel and chitosan nanoparticles with antibacterial drug release: While focused on surface coatings, the methodology could be adapted for controlled release studies of tricyclic antidepressants like Doxepin hydrochloride in biomedical applications (Carrazco Ávila et al., 2024).
- Doxepin is more effective than zolpidem in improving executive function in patients with insomnia disorder: This clinical study on Doxepin could relate directly to Doxepin hydrochloride′s use in sleep medicine and psychiatric research, illustrating its efficacy and therapeutic potential (Yu et al., 2023).
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Silenor is a registered trademark of Somaxon Pharmaceuticals, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
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Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Target Organs
Eyes
Storage Class Code
3 - Flammable liquids
WGK
WGK 1
Flash Point(F)
49.5 °F - closed cup
Flash Point(C)
9.7 °C - closed cup
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Adam Wichniak et al.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 31(181), 65-70 (2011-08-30)
Disturbed sleep is a core symptom of depression and is among diagnostic criteria for depressive episode. Effects of an antidepressant drug on sleep are important for its clinical profile. Rapid improvement of sleep quality is particularly indicated in depressed patients
Andrew D Krystal et al.
Sleep, 34(10), 1433-1442 (2011-10-04)
To evaluate the efficacy and safety of doxepin (DXP) 3 mg and 6 mg in adults diagnosed with primary insomnia. The study was a randomized, double-blind, parallel-group, placebo-controlled trial. Patients meeting DSM-IV-TR criteria for primary insomnia were randomized to 35
Anna Maślanka et al.
Journal of AOAC International, 94(6), 1791-1799 (2012-02-11)
Stability of clonazepam, diazepam, haloperidol, and doxepin was determined in acidic solutions. In addition, determination of the kinetic and thermodynamic properties of this stability was carried out. Reaction rate constants (k), half-life times (t(0.1) and t(0.5)), and activation energy (Ea)
Alan Lankford et al.
Sleep medicine, 13(2), 133-138 (2011-12-27)
The efficacy and safety of doxepin (DXP), a histamine H(1) receptor antagonist, was evaluated in elderly adults with sleep maintenance insomnia. This was a randomized, double-blind, placebo-controlled outpatient trial. Elderly adults meeting DSM-IV-TR criteria for primary insomnia were randomized to
Christopher J Jones et al.
Analytical chemistry, 84(16), 7099-7106 (2012-08-03)
The capillary isotachophoresis (cITP) separation of the isomers of the tricyclic antidepressant doxepin using β-cyclodextrin (β-CD) as a buffer additive is investigated by online microcoil NMR detection. Capillary electrophoresis (CE) is also used to determine the binding constant between the
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