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870600C

Avanti

PAzePC

Avanti Research™ - A Croda Brand 870600C

Synonym(s):

1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C33H64NO10P
CAS Number:
117746-89-1
Molecular Weight:
665.84
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 1 mL (870600C-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 870600C

concentration

1 mg/mL (870600C-1mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCC(O)=O)=O)COC(CCCCCCCCCCCCCCC)=O)=O

General description

1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PAzePC) has carboxyl groups at the end of their truncated sn-2 chains.

Application

1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PAzePC) may be used:,as an oxidized lipid dopant in liposomes for investigating the relationship between the permeation of H2O2 and the structure of lipid membranes, as a substrate for lysosomal phospholipase A2 during the study of structural basis of lysosomal phospholipase A2 inhibition by Zn2+, in the preparation of large unilamellar vesicles (LUVs) and giant unilamellar vesicles (GUVs).

Biochem/physiol Actions

1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PAzePC) is an oxidized lipid. PAzePC acts as an inter- H2O2 permeation promoter. It serves as a drug target for antipsychotic drugs and antimicrobial agents in cells under oxidative stress at inflammatory sites. PAzePC facilitates permeabilization of Bax associated-mitochondrial membranes under oxidative stress.

Packaging

5 mL Clear Glass Sealed Ampule (870600C-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mooud Amirkavei et al.
Biochimica et biophysica acta, 1858(2), 264-273 (2015-12-15)
In order to obtain molecular level insight into the biophysics of the apoptosis promoting phospholipid 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PazePC) we studied its partitioning into different lipid phases by isothermal titration calorimetry (ITC). To aid the interpretation of these data for PazePC, we
Cintia Kawai et al.
The journal of physical chemistry. B, 118(41), 11863-11872 (2014-09-24)
Fluorescence quenching of lipid-bound pyrene was used to assess the binding of cytochrome c (cyt c) to liposomes that mimic the inner mitochondrial membrane (IMM) POPC/DOPE/TOCL, with the conditions that it did or did not contain oxidized phosphatidylcholine molecules, i.e.

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