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860053P

Avanti

Ganglioside-Total

Avanti Research™ - A Croda Brand

Synonym(s):

Total Ganglioside Extract (Brain, Porcine-Ammonium Salt)

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About This Item

CAS Number:
383907-71-9
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (860053P-10mg)
pkg of 1 × 25 mg (860053P-25mg)
pkg of 1 × 50 mg (860053P-50mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)CO[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H]([C@H](O[C@@]3(C([O-])=O)O[C@@H]([C@H](O)[C@H](O)CO)[C@@](NC(C)=O)([H])[C@@H](O)C3)[C@H]2O)O[C@@H]4O[C@H](CO)[C@@H]([C@H](O[C@@H]5O[C@H

General description

Gangliosides are glycosphingolipids, that contain sialic acid residues in the glycan chain. They are mainly present on the surface of neuronal cells. Gangliosides are also present in serum. Four complex ganglioside structures, such as GM1, GD1a, GD1b and GT1b are the most abundantly found ganglioside in mammalian brains. Gangliosides comprise a ceramide tail attached to a polar carbohydrate head.

Application

Ganglioside-Total may be used:
  • as a standard to investigate the efficiency of ganglioside extraction in brain using electrospray ionization-mass spectrometry (ESI MS) analysis
  • as a hemagglutinin (HA) binding receptor to assemble nanodisc with affinity to influenza virus (NDTG) and also to determine the effect of total ganglioside extract (TG) amount on total ganglioside
  • in liposomes to measure ostreolysin A (OlyA) binding in order to deduce the effects of phosphatidylcholines (PCs) on sphingomyelin

Biochem/physiol Actions

Gangliosides regulate various biological activities in cell plasma membranes (PMs). It provides structural rigidity to the cell. Ganglioside clusters form membrane microdomains, which facilitates cell adhesion. It also functions as differentiating markers during oncogenesis, embryogenesis, lymphoid differentiation and neoplastic transformation. Gangliosides have the ability to repress cell-mediated immune functions. It is also associated with cancer and Alzheimer′s disease.

Packaging

5 mL Amber Glass Screw Cap Vial (860053P-10mg)
5 mL Amber Glass Screw Cap Vial (860053P-25mg)
5 mL Amber Glass Screw Cap Vial (860053P-50mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sum-frequency vibrational spectroscopy (SFVS) is used to measure the intrinsic rate of lipid flip-flop for 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), and 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) in planar-supported lipid bilayers (PSs). Asymmetric PSLBs were prepared using the Langmuir-Blodgett/Langmuir-Schaefer method by placing a perdeuterated lipid
Yangyang Zhang et al.
Scientific reports, 6, 25289-25289 (2016-05-05)
Gangliosides are a family of complex lipids that are abundant in the brain. There is no doubt the investigations about the distribution of gangliosides in brian and the relationship between gangliosides and Alzheimer's disease is profound. However, these investigations are
Byoungjae Kong et al.
Nature communications, 10(1), 185-185 (2019-01-16)
Membrane-disrupting agents that selectively target virus versus host membranes could potentially inhibit a broad-spectrum of enveloped viruses, but currently such antivirals are lacking. Here, we develop a nanodisc incorporated with a decoy virus receptor that inhibits virus infection. Mechanistically, nanodiscs
Hyunsook Kim et al.
Neuroscience letters, 603, 19-24 (2015-07-21)
Lysophosphatidic acid (LPA) is a simple and minor phospholipid, but serves as a lipid-derived neurotransmitter via activation of G protein-coupled LPA receptors. Astrocytes abundantly express LPA receptors and contain gliotransmitters that modulate astrocyte-neuron interactions. Gintonin is a novel ginseng-derived G

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