850188P

18:0-20:4 PI(3,4)P2

powder

• Synonym(s): 1-stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′-bisphosphate) (ammonium salt)
• Empirical Formula (Hill Notation): C₄₇H₉₄N₃O₁₉P₃
• CAS Number: 2315262-41-8
• Molecular Weight: 1098.18
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• Assay: 99% (TLC)
• form: powder
• packaging: package of 1 × 100 μg (850188P-100UG); package of 1 × 500 μg (850188P-500UG)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• lipid type: phospholipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](OP([O-])(O)=O)[C@@H](OP(O)([O-])=O)[C@H]1O)=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]

Description

General description

PI(3,4)P₂ is a lipid secondary messenger. It is obtained from the dephosphorylation of PI(3,4,5)P₃ by 5-phosphatase.

Biochem/physiol Actions

PI(3,4)P₂ plays a role in protein kinase B (PKB) phosphorylation on Ser473 in mast cells. It also binds to certain effectors such as serine/threonine-specific protein kinase (AKT) and dual adaptor of phosphotyrosine and 3-phosphoinositides 1 (DAPP1). It also regulates the activity of actin mesh which is associated with endocytic structures.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850188P-100UG)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850188P-500UG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable