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Key Documents

700047P

Avanti

5α,6α-epoxycholestanol-d7

Avanti Polar Lipids

Synonym(s):

cholestanol, 5α,6α-epoxy-d7

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About This Item

Empirical Formula (Hill Notation):
C27H39O2D7
CAS Number:
Molecular Weight:
409.70
UNSPSC Code:
12352100
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700047P-1mg)

manufacturer/tradename

Avanti Polar Lipids

shipped in

dry ice

storage temp.

−20°C

General description

5α,6α-epoxycholestanol (5α,6α-EC) is generated by cholesterol epoxidation. 5α,6α-epoxycholestanol-d7 is a deuterated derivative of 5α,6α-EC. It is catabolized by the enzyme cholesterol-5,6-epoxide hydrolase (ChEH) enzyme to 3β,5α,6β-triol.

Application

5α,6α-epoxycholestanol-d7 has been used as an internal standard in isotope dilution-mass spectrometry analysis of heart mitochondrial samples. It may be used as an internal standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis of plasma samples.

Biochem/physiol Actions

5α,6α-epoxycholestanol (5α,6α-EC) is a liver X receptor (LXR) antagonist. 5α,6α-EC is employed in anticancer treatments. It impairs redox state and affects atherogenesis. The levels of 5α,6α-EC are elevated in hypercholesterolemia. It mediates steroid receptor coactivator (SRC) recruitment.

Packaging

5 mL Amber Glass Screw Cap Vial (700047P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Description
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Storage Class Code

11 - Combustible Solids


Certificates of Analysis (COA)

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