Recommended Products
type
for DNA synthesis
Quality Level
product line
Proligo Reagents
concentration
97.0-119.0 g/L (acetic anhydride, titration)
color
clear colorlessto brownish
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General description
Cap A solution consists of acetic anhydrideanhydride, lutidine, and tetrahydrofuran (THF).
Application
Cap A solution is used after the phosphoramidite reaction/coupling step.
Biochem/physiol Actions
Cap A solution aborts chains bearing unreacted 5′ hydroxyl groups due to failure of reaction with activated phosphoramidite (typically, 1 to 2% of growing oligonucleotide chains in each synthesis cycle). These unreacted 5′ hydroxyl groups are capped with an acetyl group and thus rendered unreactive for subsequent synthesis steps.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Irrit. 2
Supplementary Hazards
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Certificates of Analysis (COA)
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