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933546

Sigma-Aldrich

NanoFabTx™ - Natural Folate Lipid Mix

for synthesis of folate functionalized liposomes for targeted delivery

Synonym(s):

Cholesterol, EggPC, Folate-PEG-DSPE, PE-PEG

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.21

Quality Level

100

storage temp.

−20°C

Application

NanoFabTx™ Natural Folate Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of folate-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of therapeutic drug molecules for targeted drug delivery applications without the need for lengthy trial-and-error optimization.
NanoFabTx™ Natural Folate Lipid Mix is a lyophilized, curated, lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve liposomes of approximately 100nm in diameter. The synthesized folate-functionalized liposomes can be used to selectively target cells which overexpress folate receptors such as HeLa cells and delivery hydrophilic or hydrophobic drugs, including therapeutics that are thermo-sensitive.

Features and Benefits

  • A ready-to-use nanoformulation lipid blend for the synthesis of folate-functionalized liposomes without the need for high temepratures
  • Step-by-step protocols developed and tested by our formulation scientists
  • Flexible synthesis tool to create uniform and reproducible liposomes
  • Optimized to make liposomes around 100 nm with low polydispersity
  • Optimized lipid blend for folate-functionalized liposomes for therapeutic encapsulation
For microfluidic liposome synthesis of azide-functionalized liposomes, the NanoFabTx™- Natural Folate Lipid Mix can be used with the the NanoFabTx™Microfluidic - nano device kit (Cat.No. 911593). The NanoFabTx™Microfluidic - nano device kit includes the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Mahmoud M Omar et al.
International journal of nanomedicine, 16, 683-700 (2021-02-05)
To develop an externally triggered rapid-release targeted system for treating ovarian cancer, gemcitabine (GMC) was entrapped into sonosensitive (SoS) folate (Fo)-modified liposomes (LPs). GMC-loaded LPs (GMC LPs), GMC-loaded Fo-targeted LPs (GMC-Fo LPs), and GMC-loaded Fo-targeted SoS LPs (GMC-SoS Fo LPs)
Yan Tie et al.
Signal transduction and targeted therapy, 5(1), 6-6 (2020-04-17)
Tumor-associated macrophages (TAMs) facilitate cancer progression by promoting tumor invasion, angiogenesis, metastasis, inflammatory responses, and immunosuppression. Folate receptor β (FRβ) is overexpressed in TAMs. However, the clinical significance of FRβ-positive macrophages in lung cancer remains poorly understood. In this study

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