930547

Pomalidomide-PEG₁-C₂-azide

≥95.0%

• Synonym(s): 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-((2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione, 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
• Empirical Formula (Hill Notation): C₁₇H₁₈N₆O₅
• CAS Number: 2271036-44-1
• Molecular Weight: 386.36
• UNSPSC Code: 12352125
• NACRES: NA.21

Properties

• ligand: pomalidomide
• Quality Level: 100
• Assay: ≥95.0%
• form: powder
• functional group: azide
• storage temp.: 2-8°C
• SMILES string: [N-]=[N+]=NCCOCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3

Description

Application

Pomalidomide-PEG₁-C₂-azide is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Contains an alkyne, allowing for conjugation through click chemistry. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable