911496
Polyester bis-MPA dendron, 4 carboxyl, 1 Rhodamine (core)
generation 2
Synonym(s):
Bis-MPA dendron, Fluorescent linker, Fluoresent dendron
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About This Item
Empirical Formula (Hill Notation):
C67H87ClN2O28
Molecular Weight:
1403.86
UNSPSC Code:
12162002
NACRES:
NA.23
form
solid
mol wt
generation 2
no. Surface Groups
4
color
red to pink
functional group
(Rhodamine(core))
storage temp.
−20°C
Related Categories
General description
- Polymer architecture: Dendron
- End Group Functionality: Carboxyl
- Bis-MPA: 2,2-Bis(hydroxymethyl)propionic acid
Application
Bis-MPA dendritic molecules are based on 2,2-bismethylolpropionicacid (bis-MPA) building blocks. The hydrolysable linkers presented in this type of polymers allow their degradation into byproducts that can be reabsorbed by the body or into excretable non-toxic small molecules. Therefore, this group of dendritic polymers is biocompatible and biodegradable, making them suitable for biomedical applications.
The corona of this product is functionalized by carboxyl groups, which can be readily used in bioconjugation. The rhodamine labeled core allows its application in bioimaging.
The corona of this product is functionalized by carboxyl groups, which can be readily used in bioconjugation. The rhodamine labeled core allows its application in bioimaging.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Patrik Stenström et al.
Molecules (Basel, Switzerland), 23(8) (2018-08-17)
Herein, we present the first evaluation of cationic dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) as nonviral vectors for transfection of short interfering RNA (siRNA) in cell cultures. The study encompassed dendrimers of generation one to four (G1⁻G4), modified to bear
Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications.
Garcia-Gallego S, et al
Progress in Polymer Science, 48, 85-110 (2015)
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been
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