900914
Methyltetrazine-NHS ester
≥95%
Synonym(s):
2,5-Dioxo-1-pyrrolidinyl 4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzeneacetate
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About This Item
Empirical Formula (Hill Notation):
C15H13N5O4
CAS Number:
Molecular Weight:
327.29
MDL number:
UNSPSC Code:
12352108
NACRES:
NA.22
Recommended Products
Quality Level
Assay
≥95%
form
powder or crystals
reaction suitability
reaction type: click chemistry
reagent type: cross-linking reagent
functional group
NHS ester
storage temp.
−20°C
SMILES string
O=C(ON1C(CCC1=O)=O)CC(C=C2)=CC=C2C3=NN=C(C)N=N3
Application
Methyltetrazine-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and a methyltetrazine, which is reactive to trans-cyclooctenes. The NHS ester reacts with primary amines (e.g. side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic pH to form covalent bonds. The short spacer arm adds minimal mass to modified molecules (230.2 daltons). It is generally used in click chemistry applications in bioconjugate chemistry.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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