283134

Hexamethyldisilathiane

synthesis grade

• Synonym(s): (TMS)₂S, HMDS, Bis(trimethylsilyl) sulfide, NSC 252160
• Linear Formula: (CH₃)₃SiSSi(CH₃)₃
• CAS Number: 3385-94-2
• Molecular Weight: 178.44
• Beilstein: 1698358
• EC Number: 222-201-4
• MDL number: MFCD00014851
• UNSPSC Code: 12352103
• PubChem Substance ID: 24857086
• NACRES: NA.23

Properties

• form: liquid
• quality: synthesis grade
• refractive index: n20/D 1.4586 (lit.)
• bp: 164 °C (lit.)
• density: 0.846 g/mL at 25 °C (lit.)
• SMILES string: C[Si](C)(C)S[Si](C)(C)C
• InChI: 1S/C6H18SSi2/c1-8(2,3)7-9(4,5)6/h1-6H3
• InChI key: RLECCBFNWDXKPK-UHFFFAOYSA-N

Description

Application

Hexamethyldisilathiane may be used in the bis-O-demethylation of dimethoxy aromatic compounds.
It may also be used as a sulfur source in the following conversion:

• Amides and lactams to their corresponding sulfur analogs.
• Allyl alcohols to diallyl sulfides.
• Transition metal halides to metal sulfides.
• Aryl iodides to diaryl sulfides.

Safety Information

• Pictograms: GHS02,GHS06
• Signal Word: Danger
• Hazard Statements: H226,H301 + H311 + H331
• Precautionary Statements: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 3
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 73.4 °F - closed cup
• Flash Point(C): 23 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves