- Hydroxynitrile lyases in stereoselective catalysis.
Hydroxynitrile lyases in stereoselective catalysis.
Current opinion in biotechnology (2000-12-05)
F Effenberger, S Förster, H Wajant
PMID11102786
RESUMO
(R)- as well as (S)-cyanohydrins are now easily available as a result of the excellent accessibility, the relatively high stability and the easy handling of hydroxynitrile lyases (HNLs). The optimization of reaction conditions (solvent, temperature, and using site-directed mutagenesis, etc.) has enabled HNL-catalyzed preparations of optically active cyanohydrins on a technical scale. The enantioselectivity of chiral metal-complex-catalyzed additions of trimethylsilyl cyanide to aldehydes has been improved, but is, by far, not yet competitive with the HNL-catalyzed reactions.
MATERIAIS