- 2-Heteroarylidene-1-indanone derivatives as inhibitors of monoamine oxidase.
2-Heteroarylidene-1-indanone derivatives as inhibitors of monoamine oxidase.
Bioorganic chemistry (2016-09-24)
Magdalena S Nel, Anél Petzer, Jacobus P Petzer, Lesetja J Legoabe
PMID27662218
RESUMO
In the present study a series of fifteen 2-heteroarylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. These compounds are structurally related to series of heterocyclic chalcone derivatives which have previously been shown to act as MAO-B specific inhibitors. The results document that the 2-heteroarylidene-1-indanones are in vitro inhibitors of MAO-B, displaying IC
MATERIAIS