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Treatment of suspected hyper-reactive malarial splenomegaly (HMS) in pregnancy with mefloquine.

The American journal of tropical medicine and hygiene (2014-03-05)
Juthamas Jaroensuk, Nicole Stoesser, Mara L Leimanis, Podjanee Jittamala, Nicholas J White, Francois H Nosten, Rose McGready
RESUMO

Malaria infections in pregnancy are associated with adverse outcomes for both mother and child. There are few data on hyper-reactive malarial splenomegaly, an aberrant immunological response to chronic or recurrent malaria in pregnancy. This retrospective assessment reviewed the impact of mefloquine treatment on pregnant women with suspected hyper-reactive malarial splenomegaly in an area of low malaria transmission in the 1990s, showing significant reductions in spleen size and anemia and anti-malarial antibody titers without any notable negative effect on treated women or their newborns.

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Sigma-Aldrich
Mefloquine hydrochloride, ≥98% (HPLC), powder
Mefloquine hydrochloride, European Pharmacopoeia (EP) Reference Standard