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  • Exposure to high dosage trihexyphenidyl during pregnancy for treatment of generalized dystonia: case report and literature review.

Exposure to high dosage trihexyphenidyl during pregnancy for treatment of generalized dystonia: case report and literature review.

The neurologist (2011-11-03)
Bradley James Robottom, Stephen G Reich
RESUMO

Trihexyphenidyl is 1 of the most effective agents for treatment of young-onset dystonia. As such, women of childbearing potential use trihexyphenidyl despite inadequate information about potential effects on pregnancy, labor, and fetal development. We report 2 uncomplicated pregnancies in 1 woman with early-onset, sporadic, primary generalized dystonia (DYT1 negative) treated with high dosage trihexyphenidyl and review the literature on antidystonic agents and pregnancy. Although there is limited data, our case demonstrates that high-dosage trihexyphenidyl treatment is not necessarily a contraindication to pregnancy.