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Merck
  • Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography.

Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography.

Angewandte Chemie (International ed. in English) (2012-06-08)
Alexander G O'Brien, Zoltán Horváth, François Lévesque, Ju Weon Lee, Andreas Seidel-Morgenstern, Peter H Seeberger
RESUMO

Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 % by coupling a flow reactor to a simulated moving bed (SMB) chromatography module.

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Sigma-Aldrich
2,4-Difluoronitrobenzene, 99%