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Merck
  • From histamine to imidazolylalkyl-sulfonamides: the design of a novel series of histamine H3-receptor antagonists.

From histamine to imidazolylalkyl-sulfonamides: the design of a novel series of histamine H3-receptor antagonists.

Bioorganic & medicinal chemistry letters (1999-07-16)
M J Tozer, E A Harper, S B Kalindjian, M J Pether, N P Shankley, G F Watt
RESUMO

Histamine was converted to a selective histamine H3-receptor antagonist by capping the primary amine with 2-naphthalenesulfonyl chloride. Higher receptor affinity and lower variability in the data from the various bioassays were achieved with the 2-naphthalensulfonamides of histamine homologues.

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Sigma-Aldrich
2-Naphthalenesulfonyl chloride, 99%