- A life-threatening flecainide overdose treated with intravenous fat emulsion.
A life-threatening flecainide overdose treated with intravenous fat emulsion.
Pacing and clinical electrophysiology : PACE (2012-08-14)
Heather Ellsworth, Samuel J Stellpflug, Jon B Cole, Joseph A Dolan, Carson R Harris
PMID22882363
RESUMO
Flecainide is a Vaughan Williams Class Ic antidysrhythmic associated with PR, QRS, and QTc prolongation on the electrocardiogram and development of life-threatening cardiac toxicity in overdose. The cornerstone of treatment is fluid resuscitation and the administration of magnesium and sodium bicarbonate. We report a case of flecainide overdose associated with life-threatening hemodynamic compromise successfully treated with intravenous fat emulsion (IFE) therapy. IFE should be considered as a novel adjunctive therapy in patients with life-threatening toxicity following flecainide overdose.