- Sulfated modification of the water-soluble polysaccharides from Polyporus albicans mycelia and its potential biological activities.
Sulfated modification of the water-soluble polysaccharides from Polyporus albicans mycelia and its potential biological activities.
International journal of biological macromolecules (2008-10-28)
Yongxu Sun, Haitao Liang, Guangzhi Cai, Shuwen Guan, Haibin Tong, Xiudong Yang, Jicheng Liu
PMID18951914
RESUMO
In this study, three chemically sulfated polysaccharides (SPAPs) were derived from one water-soluble polysaccharide (PAP) of Polyporus albicans mycelia by chlorosulfonic acid-pyridine method. The effects of polysaccharides on the immune function were examined after the mice were intragastrical administrated with polysaccharides at three doses of 100, 200, and 300 mg/kg body weight for 7 days. The results showed that both the lymphocytes proliferation and macrophage function were significantly enhanced by SPAP in all groups along with the increase of the substitution degree and dose (P<0.01). It indicated that SPAP could be a potential immunostimulants used in the food and pharmaceutical industry.
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