- Asymmetric synthesis of novel apio carbocyclic nucleoside analogues as potential antiviral and antitumor agent.
Asymmetric synthesis of novel apio carbocyclic nucleoside analogues as potential antiviral and antitumor agent.
Nucleosides, nucleotides & nucleic acids (2007-12-11)
Lak Shin Jeong, Jeong A Lee, Hyung Ryong Moon, Hea Ok Kim, Kang Man Lee, Hyun Joo Lee, Moon Woo Chun
PMID18066888
RESUMO
Novel apio carbocyclic nucleosides 18-21 were asymmetrically synthesized as potential antiviral and antitumor agent, starting from D-ribose employing aldol reaction, RCM reaction and Mitsunobu reaction as key reactions.